Global
hepatitis C therapeutics market would grow from USD 5.9 billion in 2012 to USD
19 billion in 2019. Hepatitis C, a complex liver disease, is caused by the
ribonucleic acid virus. It usually spreads through direct contact with infected
blood or blood products. Detection is very difficult as the infection is often
asymptomatic.
Hepatitis
C is of serious nature as even when detected and targeted, it continues to
establish and maintain a life-long, persistent infection. This could result in
cirrhosis and hepatocellular carcinoma. Hepatitis C is a leading cause of liver
transplantation in North America and the U.K.
No
preventive vaccine or selective antiviral therapy exists at present. Current
treatment options include a combination of ribavirin and pegylated interferon.
Patients diagnosed with genotype 1 hepatitis C are treated with one of two
direct-acting antiviral agents (DAAs).
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However,
these treatment options are not very effective. Moreover, these drugs are toxic
and lead to side effects that include fever, depression, arthralgia, and
haemolytic anemia. Also, their administration is a costly affair. Price of a
single dose ranges between few hundred dollars to thousands of dollars. Also
standard insurance covers do not reimburse complete costs.
The
virus’s lifecycle is highly complicated, making discovery of new therapies a
daunting task. DAA Sovaldi, which was approved in December 2013, has marked a
breakthrough in this space. It achieved complete viral clearance in almost 100%
of the patients. Additionally, instances of adverse events have been lower as
compared to previous therapies. In cases of genotype 2 and 3 hepatitis C,
Sovaldi need not be administered with pegylated interferon.
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Apart
from Sovaldi, several other products may be introduced in the near future.
These are expected to provide better efficacy and safety. They include multiple
interferon-free therapies for patients suffering from genotype 1 infection.
These novel products would prove favorable for market growth.
The
growth potential is attracting several players in the healthcare drugs
industry. Rising presence of Asian manufacturers will lead to cheaper products.
North America is the largest market in terms of volumes, while Europe occupies
second place. Demand in these markets is being driven by high incidence rates
and affordability.
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Table of Contents
Table
of Contents 5
1.1
List of Tables 8
1.2
List of Figures 9
2
Introduction 10
2.1
Signs and Symptoms 10
2.2
Etiology and Risk Factors 11
2.3
Pathophysiology 11
2.4
Epidemiology 12
2.4.1
US and Canada 12
2.4.2
Europe 12
2.4.3
Japan 13
2.4.4
Regional Prevalence of Hepatitis C Genotypes 13
2.5
Prognosis 14
2.6
Diagnosis and Screening 16
2.7
Treatment 16
2.8
Treatment Algorithms 17
3 Marketed Products 21
3.1
Ribavirin 21
3.2
Pegasys (Peginterferon alfa 2a) and PegIntron (Peginterferon alfa 2b) -
Hoffmann La Roche and Merck & Co 22
3.2.1
Pegasys - Hoffmann La Roche 24
3.2.2
PegIntron - Merck & Co 24
3.3
Incivek (telaprevir) - Vertex Pharmaceuticals and Janssen-Cilag 25
3.4
Victrelis (boceprevir) - Merck & Co 26
3.5
Olysio (simeprevir) - Johnson and Johnson 27
3.6
Sovaldi (sofosbuvir) - Gilead Sciences 28
3.7
Heat Map for Marketed Products 29
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